PerioVive
Transform your dental outcomes with just one dose
The PerioVive veterinary medical device is a hyaluronic acid (HA) gel that comes in a pre-filled tissue applicator for convenient and precise delivery. Studies show that a single dose of HA post-procedure accelerates tissue healing, increases bone formation, and reduces probing pocket depth across a wide range of dental settings.
PerioVive™: Advanced Hyaluronic Acid Gel
Powerful Healing for Soft Tissue and Bone Regeneration
PerioVive harnesses the natural power of hyaluronic acid (HA), a component naturally present in connective tissue. This veterinary-formulated gel delivers comprehensive support for soft tissue conditions and bone defects in a single, easy-to-apply treatment.
1. Primary Application: Periodontal Pockets
Transform Soft Tissue Healing
PerioVive demonstrates numerous beneficial effects on soft tissue healing following closed root planing and subgingival curettage. Unlike antibiotics that only fight bacteria, PerioVive reconstructs the healing environment.
- Reduced Pocket Depth (PPD): Statistically significant improvements.
- Increased Attachment: Clinical attachment level (CAL) gains.
- Reduced Inflammation: Decreased bleeding on probing (BOP).
- Patient Comfort: Reduced pain following periodontal therapy.
Follow the 4-step protocol: Diagnose, Root Plane, Curettage, and Apply.
2. The Science: How PerioVive Works
Our advanced formula works through multiple mechanisms to deliver comprehensive healing. It acts as a scaffold and space maintainer while actively modulating the cellular environment.
- Modulates Inflammation: Scavenges inflammatory cell-derived reactive oxygen species.
- Cellular Promotion: Promotes migration and differentiation of fibroblasts involved in tissue formation.
- Bacteriostatic Defense: Provides bacteriostatic effects against periodontal pathogens.
- Angiogenesis: Facilitates new blood vessel formation, crucial for wound healing.
- Osteoinduction: Stimulates bone wound healing.
3. Advanced Care: Extraction Sites & Bone Regeneration
Structural Support When It Matters Most
PerioVive isn't just for pockets; it promotes powerful regeneration in challenging areas, showing remarkable results in Class II furcation defects and intrabony defects.
- Accelerated Bone Formation: Significant improvements even in infected extraction sockets.
- Better Mineralization: Formation of new alveolar bone with greater density compared to untreated sites.
- True Regeneration: New acellular cementum and functionally oriented periodontal ligament fibers.
Combine PerioVive with an absorbable scaffold (like Gelfoam) for optimal extraction site results.
4. Clinical Efficiency & Economics
Stop struggling with difficult-to-mix gels. PerioVive offers superior usability and economics compared to traditional Doxycycline or Clindamycin gels.
Why Switch to PerioVive?
- Extended Shelf Life & Usability: You can use a single syringe for multiple pockets and between different patients for up to two weeks.
- Simple Hygiene Protocol: The recommendation is to simply change the applicator tips out between patients—no waste.
- High ROI per Tube: Each tube effectively treats 6-8 pockets.
- Superior Performance: Easier to apply than Doxyrobe or Clindoral, with twice the efficacy.
Ready to Upgrade Your Periodontal Protocol?
Give your patients the benefit of true regeneration and reduced post-op pain.
References:
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Tella, E. A., Aldahlawi, S. A., Azab, E. T., Yaghmoor, W. E., & Fansa, H. A. (2023). Histological and histomorphometric evaluation of hyaluronic acid gel with or without acellular dermal matrix allograft on periodontal regeneration in Class II furcation defects in dogs. The Saudi Dental Journal, 35(8), 846-855.
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Shirakata, Y., Nakamura, T., Kawakami, Y., Imafuji, T., Shinohara, Y., Noguchi, K., & Sculean, A. (2021). Healing of buccal gingival recessions following treatment with coronally advanced flap alone or combined with a cross-linked hyaluronic acid gel. An experimental study in dogs. Journal of Clinical Periodontology, 48(4), 570-580.
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Shirakata, Y., Imafuji, T., Nakamura, T., Kawakami, Y., Miron, R. J., Nakamura-Hasegawa, K., ... & Sculean, A. (2021). Periodontal wound healing/regeneration of two-wall intrabony defects following reconstructive surgery with cross-linked hyaluronic acid-gel with or without a collagen matrix: a preclinical study in dogs. Quintessence International, 52(3), 238-249.
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Kim, J. J., Song, H. Y., Ben Amara, H., Kyung-Rim, K., & Koo, K. T. (2016). Hyaluronic acid improves bone formation in extraction sockets with chronic pathology: A pilot study in dogs. Journal of Periodontology, 87(7), 790-795.
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Martel, K. A. (2019). Evaluation of closed root planing with or without adjunctive local antimicrobial gel application for treatment of periodontal pockets in dogs. Journal of the American Veterinary Medical Association, 254(3), 368-373.
The PerioVive Value
Comprehensive, well-established safety and efficacy
Designed specifically for veterinarians by veterinarians
Optimized route of administration for expedient application
The power of hyaluronic acid
How it works
Hyaluronic acid (HA) is a naturally occurring biomaterial that has been proven safe and effective in both humans and dogs for a variety of indications, including dentistry. Periodontal applications of HA have shown statistically significant efficacy in 5+ canine studies and 100+ human studies. Additionally, HA may prevent progression to more severe periodontal disease and reduce required tooth extraction
How it sticks
HA is extremely hydrophilic, absorbing 1000x its weight in water. When contacted with fluids such as water or blood, it increases in viscosity. And on a microscopic level, it binds to specific cell surface receptors, enhancing extracellular stability.
Hyaluronic Acid
FAQ's
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How does PerioVive help with my dog’s gum healing after a dental cleaning or extraction?
PerioVive contains hyaluronic acid, which accelerates gum tissue repair and reduces post-procedure pain and inflammation.
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How does PerioVive reduce inflammation and support oral tissue repair?
It soothes irritated tissues, reduces bleeding, and promotes healthy cell regeneration for faster healing.
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How does PerioVive help treat periodontal disease and promote bone regeneration?
It supports new bone growth in damaged areas and helps rebuild the structures that support the teeth.
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Can I use PerioVive for my dog’s gingival recession or bleeding gums?
Yes, it helps reduce pocket depth, improves gum attachment, and minimizes bleeding.
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Can I use PerioVive to support my dog’s recovery after a tooth extraction?
Absolutely—PerioVive speeds up healing, reduces discomfort, and lowers the risk of infection at extraction sites.
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